Autism Spectrum Disorder – Advances in Genomics and Impact of Early Behavioral Intervention

  • Beena Johnson Department of Child Guidance, Baby Memorial Hospital.

Abstract

Autism spectrum disorder is a developmental dis­order characterized by persistent deficits in social interaction and communication, as well as by restricted, repetitive patterns of behavior or activities. It is a complex polygenic disorder. It occurs due to altered gene-environmental interac­tion. There are several single nucleotide polymorphisms associated with autism spectrum disorder. Copy number variations are detected in several autism spectrum disorder probands. Recent studies have found novel candidate genes and point mutations associated with this disorder. Abnormal synaptic homeostasis is found to be a risk factor for autism spectrum disorder. Several risk genes are the key regulators of synaptic plasticity. Rare de novo and inherited copy number variations have been implicated in the genetic risk factors. The key to successful management of autism spectrum disorder is early behavioral intervention. Infant "at risk" should be provided very early intervention before full syndrome is present. Parent training interventions have an important role in the management of these children. Early interventions will improve the intelligence, adaptive behavior as well as the social and communication skills of the children with autism spectrum disorder.
Published
2018-03-28
How to Cite
JOHNSON, Beena. Autism Spectrum Disorder – Advances in Genomics and Impact of Early Behavioral Intervention. BMH Medical Journal - ISSN 2348–392X, [S.l.], v. 5, n. 2, p. 57-62, mar. 2018. ISSN 2348-392X. Available at: <https://www.babymhospital.org/BMH_MJ/index.php/BMHMJ/article/view/171>. Date accessed: 28 mar. 2024.
Section
Review Articles

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