A Prospective Randomised Double Blind Study To Compare The Effects Of Intrathecal Isobaric Ropivacaine And Levobupivacaine For Spinal Anaesthesia In Transurethral Resection Of Prostate

Abstract

 
Introduction: Subarachnoid block (SAB) is the most popular as well as effective technique for infraumbilical surgeries. It provides fast onset and effective sensory and motor blockade. In this study we tried to compare the clinical effects of 0.75% isobaric ropivacaine and 0.5% isobaric levobupivacaine in spinal anaesthesia for transurethral resection of prostate.
Material And Methods: a prospective randomised double blind controlled study was conducted on 70 patients aged 45-75 of ASA physical status I-II , posted for transurethral resection of prostate . The patients were divided into 2 groups A and B. group A received 3 ml of 0.75% isobaric ropivacaine and group B received 3 ml of 0.5% isobaric levobupivacaine. The patients were assessed for the onset and duration of motor and sensory block, time for 2 segment regression of sensory block, time of request of analgesic, hemodynamic parameters and side effects. The results were compared using students t test and chi-square test. P value of <0.05 was considered significant.
Results: The onset of sensory and motor blockade was similar in both the groups. Ropivacaine has shorter duration of motor and sensory blockade compared to levobupivacaine. Time for 2 segment regression was also shorter in ropivacaine. Time of first request of analgesic was comparable in both the groups. There was no statistically significant difference in hemodynamic parameters and incidence of side effects.
Concusion: Isobaric Ropivacaine has shorter duration of sensory and motor block compared to isobaric Levobupivacaine. However, equivalent doses of Ropivacaine and Levobupivacaine has similar onset of sensory and motor block with comparable hemodynamic parameters and no significant side effects.