Outbreak of Enterovirus - 71 Meningitis in Calicut

  • CK Sasidharan Baby Memorial Hospital , Calicut
  • KG Alexander Baby Memorial Hospital , Calicut
  • Shashi Khare National Centre for Disease Control , New Delhi
  • V Ajay Baby Memorial Hospital , Calicut.
  • Satish Nunna Baby Memorial Hospital, Calicut.
  • Meena Datt Research Assistant in Microbiology, National Centre for Disease Control, New Delhi.


ABSTRACTObjective: Enterovirus 71(EV 71) causes  wide spectrum of infections ranging from asymptomatic conditions to clinical syndromes like diarrhea, rash, hand-foot-and mouth disease (HFMD), herpangina, aseptic meningitis, encephalitis, myocarditis, acute flaccid paralysis, bulbar and brainstem encephalitis Guillain Barre syndrome, pulmonary haemorrhage. This study deals with an outbreak of aseptic meningitis in children caused by EV 71 virus. Methods: The authors report an outbreak of aseptic meningitis in children in and around Calicut in June 2008. Clinical and laboratory study was done in collaboration with National Centre for Disease Control, New Delhi. 149 children with aseptic meningitis were studied and followed up from June 2008 to May 2009.Result: All children had clinical features suggestive of aseptic meningitis and serology showed the rising antibody titre against EV 71 virus infection. CSF analysis also showed four fold rise in antibodies in one and  ≥ 1:2 neutralising antibodies titer against EV- 71 in four samples indicating meningitis due to EV-71.Conclusion:EV 71 was identified as the causative agent of the outbreak of aseptic meningitis in the study and the fact that the EV 71 infection has evolved from minor illness like HFMD to major illness like aseptic meningitis from the same locality is truly alarming. Key words: Aseptic Meningitis, Enterovirus 71 

Author Biographies

CK Sasidharan, Baby Memorial Hospital , Calicut
Senior ConsultantPaediatrics
KG Alexander, Baby Memorial Hospital , Calicut
Senior Consultant Physician and Managing Director
Shashi Khare, National Centre for Disease Control , New Delhi
Additional Director and Head (Microbiology ),
V Ajay, Baby Memorial Hospital , Calicut.
Registrar in Paediatrics
Satish Nunna, Baby Memorial Hospital, Calicut.
Junior Resident in Paediatrics


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How to Cite
SASIDHARAN, CK et al. Outbreak of Enterovirus - 71 Meningitis in Calicut. BMH Medical Journal - ISSN 2348–392X, [S.l.], v. 3, n. 2, p. 37-42, feb. 2016. ISSN 2348-392X. Available at: <https://www.babymhospital.org/BMH_MJ/index.php/BMHMJ/article/view/91>. Date accessed: 22 july 2024.
Research Article